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Hetero-oligomerization of Rho and Ras GTPases Connects GPCR Activation to mTORC2-AKT Signaling

The activation of G-protein-coupled receptors (GPCRs) leads to the activation of mTORC2 in cell migration and metabolism. However, the mechanism that links GPCRs to mTORC2 remains unknown. Here, using Dictyostelium cells, we show that GPCR-mediated chemotactic stimulation induces hetero-oligomerizat...

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Bibliografiska uppgifter
I publikationen:Cell Rep
Huvudupphovsmän: Senoo, Hiroshi, Wai, May, Matsubayashi, Hideaki T., Sesaki, Hiromi, Iijima, Miho
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2020
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7716479/
https://ncbi.nlm.nih.gov/pubmed/33238110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108427
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