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The FGFR1 V561M Gatekeeper Mutation Drives AZD4547 Resistance through STAT3 Activation and EMT
Fibroblast growth factor receptor 1 (FGFR1) has been implicated in numerous cancer types including squamous cell lung cancer, a subset of non-small cell lung cancer (NSCLC) with a dismal 5-year survival rate. Small molecule inhibitors targeting FGFR1 are currently in clinical trials, with AZD4547 be...
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| Veröffentlicht in: | Mol Cancer Res |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6647014/ https://ncbi.nlm.nih.gov/pubmed/30257990 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-18-0429 |
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