FGFR inhibitor, AZD4547, impedes the stemness of mammary epithelial cells in the premalignant tissues of MMTV-ErbB2 transgenic mice

The fibroblast growth factor receptor (FGFR) family of receptor tyrosine kinases (RTKs) regulates signaling pathways involved in cell proliferation and differentiation. Currently, the anti-tumor properties of FGFR inhibitors are being tested in preclinical and clinical studies. Nevertheless, reports...

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Detalhes bibliográficos
Publicado no:Sci Rep
Principais autores: Zhao, Qingxia, Parris, Amanda B., Howard, Erin W., Zhao, Ming, Ma, Zhikun, Guo, Zhiying, Xing, Ying, Yang, Xiaohe
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5595825/
https://ncbi.nlm.nih.gov/pubmed/28900173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11751-7
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