Buformin inhibits the stemness of erbB-2-overexpressing breast cancer cells and premalignant mammary tissues of MMTV-erbB-2 transgenic mice

BACKGROUND: Metformin, an FDA-approved drug for the treatment of Type II diabetes, has emerged as a promising anti-cancer agent. Other biguanide analogs, including buformin and phenformin, are suggested to have similar properties. Although buformin was shown to reduce mammary tumor burden in carcino...

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Опубликовано в: :J Exp Clin Cancer Res
Главные авторы: Parris, Amanda B., Zhao, Qingxia, Howard, Erin W., Zhao, Ming, Ma, Zhikun, Yang, Xiaohe
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2017
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Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5307817/
https://ncbi.nlm.nih.gov/pubmed/28193239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-017-0498-0
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