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The FGFR1 V561M Gatekeeper Mutation Drives AZD4547 Resistance through STAT3 Activation and EMT

Fibroblast growth factor receptor 1 (FGFR1) has been implicated in numerous cancer types including squamous cell lung cancer, a subset of non-small cell lung cancer (NSCLC) with a dismal 5-year survival rate. Small molecule inhibitors targeting FGFR1 are currently in clinical trials, with AZD4547 be...

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Bibliografske podrobnosti
izdano v:Mol Cancer Res
Main Authors: Ryan, Molly R., Sohl, Christal D., Luo, BeiBei, Anderson, Karen S
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6647014/
https://ncbi.nlm.nih.gov/pubmed/30257990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-18-0429
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