Insight into resistance mechanisms of AZD4547 and E3810 to FGFR1 gatekeeper mutation via theoretical study

Inhibitors targeting the amplification of the fibroblast growth factor receptor 1 (FGFR1) have found success in the treatment of FGFR1-positive squamous cell lung and breast cancers. A secondary mutation of gatekeeper residue (V561M) in the binding site has been linked to the acquired resistance. Re...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Drug Des Devel Ther
Main Authors: Liang, Donglou, Chen, Qiaowan, Guo, Yujin, Zhang, Ting, Guo, Wentao
Format: Artigo
Jezik:Inglês
Izdano: Dove Medical Press 2017
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5322841/
https://ncbi.nlm.nih.gov/pubmed/28255231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S129991
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki