AZD4547 Attenuates Lipopolysaccharide-Induced Acute Kidney Injury by Inhibiting Inflammation: The Role of FGFR1 in Renal Tubular Epithelial Cells

INTRODUCTION: Inflammation plays an important role in the pathogenesis of acute kidney injury (AKI). Fibroblast growth factor receptor 1 (FGFR1) signaling is implicated in kidney pathology. AZD4547 is a small molecule inhibitor of FGFR1. MATERIALS AND METHODS: Here, we investigated whether AZD4547 c...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Chen, Xuemei, Zhang, Xuejiao, Xu, Jiajun, Zhao, Yiqing, Bao, Jiachun, Zheng, Zhanxiong, Han, Jibo
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2020
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7049771/
https://ncbi.nlm.nih.gov/pubmed/32161443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S224343
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