Discovery of SHR9352: A Highly Potent G Protein-Biased μ-Opioid Receptor Agonist

[Image: see text] Recently, targeting the G protein-biased signaling has emerged as an attractive therapeutic strategy for treating severe acute pain with the potential to reduce the side effect of the traditional opioid drug. Herein, we describe the discovery of a highly potent G protein-biased μ-o...

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Pubblicato in:ACS Omega
Autori principali: Li, Xin, He, Wei, Chen, Yang, Yang, Guimei, Wan, Hong, Zhang, Lei, Hu, Qiyue, Feng, Jun, Zhang, Zhigao, He, Feng, Bai, Chang, Zhang, Lianshan, You, Li, Tao, Weikang
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2017
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6645658/
https://ncbi.nlm.nih.gov/pubmed/31457439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.7b01452
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