Discovery of SHR1653, a Highly Potent and Selective OTR Antagonist with Improved Blood–Brain Barrier Penetration

[Image: see text] The oxytocin receptor (OTR) plays a major role in the control of male sexual responses. Antagonists of the OTR have been reported to inhibit ejaculation in animal models and serve as a potential treatment for premature ejaculation (PE). Herein, we describe a novel scaffold featurin...

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Udgivet i:ACS Med Chem Lett
Main Authors: Li, Xin, Zhang, Zhigao, Chen, Yang, Wan, Hong, Sun, Jiakang, Wang, Bin, Feng, Bingqiang, Hu, Bing, Shi, Xingxing, Feng, Jun, Zhang, Lei, He, Feng, Bai, Chang, Zhang, Lianshan, Tao, Weikang
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2019
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6580551/
https://ncbi.nlm.nih.gov/pubmed/31223461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00186
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