Discovery of Imidazoisoindole Derivatives as Highly Potent and Orally Active Indoleamine-2,3-dioxygenase Inhibitors

[Image: see text] A novel series of imidazoisoindoles were identified as potent indoleamine-2,3-dioxygenase (IDO) inhibitors. Lead optimization toward improving potency and eliminating CYP inhibition resulted in the discovery of lead compound 25, a highly potent IDO inhibitor with favorable pharmaco...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Tu, Wangyang, Yang, Fanglong, Xu, Guoji, Chi, Jiangtao, Liu, Zhiwei, Peng, Wei, Hu, Bing, Zhang, Lei, Wan, Hong, Yu, Nan, Jin, Fangfang, Hu, Qiyue, Zhang, Lianshan, He, Feng, Tao, Weikang
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6580535/
https://ncbi.nlm.nih.gov/pubmed/31223453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00114
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