Discovery of Imidazoisoindole Derivatives as Highly Potent and Orally Active Indoleamine-2,3-dioxygenase Inhibitors

[Image: see text] A novel series of imidazoisoindoles were identified as potent indoleamine-2,3-dioxygenase (IDO) inhibitors. Lead optimization toward improving potency and eliminating CYP inhibition resulted in the discovery of lead compound 25, a highly potent IDO inhibitor with favorable pharmaco...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:ACS Med Chem Lett
Main Authors: Tu, Wangyang, Yang, Fanglong, Xu, Guoji, Chi, Jiangtao, Liu, Zhiwei, Peng, Wei, Hu, Bing, Zhang, Lei, Wan, Hong, Yu, Nan, Jin, Fangfang, Hu, Qiyue, Zhang, Lianshan, He, Feng, Tao, Weikang
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2019
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6580535/
https://ncbi.nlm.nih.gov/pubmed/31223453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00114
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki