Determinants of Oligonucleotide Selectivity of APOBEC3B

APOBEC3B (A3B) is a prominent source of mutation in many cancers. To date, it has been difficult to capture the native protein-DNA interactions that confer A3B’s substrate specificity by crystallography due to the highly dynamic nature of wild-type A3B active site. We use computational tools to rest...

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Bibliografiska uppgifter
I publikationen:J Chem Inf Model
Huvudupphovsmän: Wagner, Jeffrey R., Demir, Özlem, Carpenter, Michael A., Aihara, Hideki, Harki, Daniel A., Harris, Reuben S., Amaro, Rommie E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6644697/
https://ncbi.nlm.nih.gov/pubmed/30130104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jcim.8b00427
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