Selection and Characterization of a Nanobody Biosensor of GTP-Bound RHO Activities

RHO (Ras HOmologous) GTPases are molecular switches that activate, in their state bound to Guanosine triphosphate (GTP), key signaling pathways, which involve actin cytoskeleton dynamics. Previously, we selected the nanobody RH12, from a synthetic phage display library, which binds the GTP-bound act...

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Vydáno v:Antibodies (Basel)
Hlavní autoři: Keller, Laura, Bery, Nicolas, Tardy, Claudine, Ligat, Laetitia, Favre, Gilles, Rabbitts, Terence H., Olichon, Aurélien
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6640709/
https://ncbi.nlm.nih.gov/pubmed/31544814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antib8010008
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