Selection and Characterization of a Nanobody Biosensor of GTP-Bound RHO Activities

RHO (Ras HOmologous) GTPases are molecular switches that activate, in their state bound to Guanosine triphosphate (GTP), key signaling pathways, which involve actin cytoskeleton dynamics. Previously, we selected the nanobody RH12, from a synthetic phage display library, which binds the GTP-bound act...

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Bibliographic Details
Published in:Antibodies (Basel)
Main Authors: Keller, Laura, Bery, Nicolas, Tardy, Claudine, Ligat, Laetitia, Favre, Gilles, Rabbitts, Terence H., Olichon, Aurélien
Format: Artigo
Language:Inglês
Published: MDPI 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6640709/
https://ncbi.nlm.nih.gov/pubmed/31544814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antib8010008
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