Increased Lysosomal Exocytosis Induced by Lysosomal Ca(2+) Channel Agonists Protects Human Dopaminergic Neurons from α-Synuclein Toxicity

The accumulation of misfolded proteins is a common pathological feature of many neurodegenerative disorders, including synucleinopathies such as Parkinson's disease (PD), which is characterized by the presence of α-synuclein (α-syn)-containing Lewy bodies. However, although recent studies have...

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Foilsithe in:J Neurosci
Main Authors: Tsunemi, Taiji, Perez-Rosello, Tamara, Ishiguro, Yuta, Yoroisaka, Asako, Jeon, Sohee, Hamada, Kana, Rammonhan, Malini, Wong, Yvette C., Xie, Zhong, Akamatsu, Wado, Mazzulli, Joseph R., Surmeier, D. James, Hattori, Nobutaka, Krainc, Dimitri
Formáid: Artigo
Teanga:Inglês
Foilsithe: Society for Neuroscience 2019
Ábhair:
Research Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6636071/
https://ncbi.nlm.nih.gov/pubmed/31097622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3085-18.2019
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