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Participation of Transmembrane Domain 1 of Presenilin 1 in the Catalytic Pore Structure of the γ-Secretase

γ-Secretase is an intramembrane-cleaving protease that is responsible for the generation of amyloid-β peptides linked to the pathogenesis of Alzheimer's disease. Using a substituted cysteine accessibility method, we have previously shown that the hydrophilic “catalytic pore” structure of γ-secr...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Takagi, Shizuka, Tominaga, Aya, Sato, Chihiro, Tomita, Taisuke, Iwatsubo, Takeshi
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6633739/
https://ncbi.nlm.nih.gov/pubmed/21106832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3318-10.2010
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