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Participation of Transmembrane Domain 1 of Presenilin 1 in the Catalytic Pore Structure of the γ-Secretase
γ-Secretase is an intramembrane-cleaving protease that is responsible for the generation of amyloid-β peptides linked to the pathogenesis of Alzheimer's disease. Using a substituted cysteine accessibility method, we have previously shown that the hydrophilic “catalytic pore” structure of γ-secr...
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| Izdano u: | J Neurosci |
|---|---|
| Glavni autori: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Society for Neuroscience
2010
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6633739/ https://ncbi.nlm.nih.gov/pubmed/21106832 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3318-10.2010 |
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