Norepinephrine Promotes Microglia to Uptake and Degrade Amyloid β Peptide through Upregulation of Mouse Formyl Peptide Receptor 2 and Induction of Insulin-Degrading Enzyme

Locus ceruleus (LC) is the main subcortical site of norepinephrine synthesis. In Alzheimer's disease (AD) patients and rodent models, degeneration of LC neurons and reduced levels of norepinephrine in LC projection areas are significantly correlated with the increase in amyloid plaques, neurofi...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Kong, Yan, Ruan, Lingfei, Qian, Lihua, Liu, Xiaolei, Le, Yingying
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2010
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6633413/
https://ncbi.nlm.nih.gov/pubmed/20810904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2985-10.2010
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