Presenilin 1 phosphorylation regulates amyloid-β degradation by microglia

Amyloid-β peptide (Aβ) accumulation in the brain is a hallmark of Alzheimer’s Disease. An important mechanism of Aβ clearance in the brain is uptake and degradation by microglia. Presenilin 1 (PS1) is the catalytic subunit of γ-secretase, an enzyme complex responsible for the maturation of multiple...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Psychiatry
Prif Awduron: Ledo, Jose Henrique, Liebmann, Thomas, Zhang, Ran, Chang, Jerry C., Azevedo, Estefania P., Wong, Eitan, Silva, Hernandez Moura, Troyanskaya, Olga G., Bustos, Victor, Greengard, Paul
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7881060/
https://ncbi.nlm.nih.gov/pubmed/32792660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41380-020-0856-8
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