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Presenilin 1 phosphorylation regulates amyloid-β degradation by microglia
Amyloid-β peptide (Aβ) accumulation in the brain is a hallmark of Alzheimer’s Disease. An important mechanism of Aβ clearance in the brain is uptake and degradation by microglia. Presenilin 1 (PS1) is the catalytic subunit of γ-secretase, an enzyme complex responsible for the maturation of multiple...
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| Publié dans: | Mol Psychiatry |
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| Auteurs principaux: | , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group UK
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7881060/ https://ncbi.nlm.nih.gov/pubmed/32792660 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41380-020-0856-8 |
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