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Evidence for phosphorylation and oligomeric assembly of presenilin 1

Pathogenic mutations in presenilin 1 (PS1) are associated with ≈50% of early-onset familial Alzheimer disease. PS1 is endoproteolytically cleaved to yield a 30-kDa N-terminal fragment (NTF) and an 18-kDa C-terminal fragment (CTF). Using COS7 cells transfected with human PS1, we have found that phorb...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Seeger, Mary, Nordstedt, Christer, Petanceska, Suzana, Kovacs, Dora M., Gouras, Gunnar K., Hahne, Solveig, Fraser, Paul, Levesque, Lyne, Czernik, Andrew J., George-Hyslop, Peter St, Sisodia, Sangram S., Thinakaran, Gopal, Tanzi, Rudolph E., Greengard, Paul, Gandy, Sam
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1997
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24636/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9144195/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.10.5090
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