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Norepinephrine Promotes Microglia to Uptake and Degrade Amyloid β Peptide through Upregulation of Mouse Formyl Peptide Receptor 2 and Induction of Insulin-Degrading Enzyme

Locus ceruleus (LC) is the main subcortical site of norepinephrine synthesis. In Alzheimer's disease (AD) patients and rodent models, degeneration of LC neurons and reduced levels of norepinephrine in LC projection areas are significantly correlated with the increase in amyloid plaques, neurofi...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Kong, Yan, Ruan, Lingfei, Qian, Lihua, Liu, Xiaolei, Le, Yingying
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6633413/
https://ncbi.nlm.nih.gov/pubmed/20810904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2985-10.2010
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