Statins Promote the Degradation of Extracellular Amyloid β-Peptide by Microglia via Stimulation of Exosome-associated Insulin-degrading Enzyme (IDE) Secretion

Epidemiological studies indicate that intake of statins decrease the risk of developing Alzheimer disease. Cellular and in vivo studies suggested that statins might decrease the generation of the amyloid β-peptide (Aβ) from the β-amyloid precursor protein. Here, we show that statins potently stimula...

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Autores principales: Tamboli, Irfan Y., Barth, Esther, Christian, Leonie, Siepmann, Martin, Kumar, Sathish, Singh, Sandesh, Tolksdorf, Karen, Heneka, Michael T., Lütjohann, Dieter, Wunderlich, Patrick, Walter, Jochen
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988346/
https://ncbi.nlm.nih.gov/pubmed/20876579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.149468
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