Statins Promote the Degradation of Extracellular Amyloid β-Peptide by Microglia via Stimulation of Exosome-associated Insulin-degrading Enzyme (IDE) Secretion

Epidemiological studies indicate that intake of statins decrease the risk of developing Alzheimer disease. Cellular and in vivo studies suggested that statins might decrease the generation of the amyloid β-peptide (Aβ) from the β-amyloid precursor protein. Here, we show that statins potently stimula...

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Detalhes bibliográficos
Main Authors: Tamboli, Irfan Y., Barth, Esther, Christian, Leonie, Siepmann, Martin, Kumar, Sathish, Singh, Sandesh, Tolksdorf, Karen, Heneka, Michael T., Lütjohann, Dieter, Wunderlich, Patrick, Walter, Jochen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988346/
https://ncbi.nlm.nih.gov/pubmed/20876579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.149468
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