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Activation of Microglia Acidifies Lysosomes and Leads to Degradation of Alzheimer Amyloid Fibrils
Microglia are the main immune cells of the brain, and under some circumstances they can play an important role in removal of fibrillar Alzheimer amyloid β peptide (fAβ). Primary mouse microglia can internalize fAβ, but they do not degrade it efficiently. We compared the level of lysosomal proteases...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Cell Biology
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1838985/ https://ncbi.nlm.nih.gov/pubmed/17314396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E06-10-0975 |
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