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Degradation of fibrillar forms of Alzheimer’s amyloid β-peptide by macrophages
Cultured microglia internalize fibrillar amyloid Aβ (fAβ) and deliver it to lysosomes. Degradation of fAβ by microglia is incomplete, but macrophages degrade fAβ efficiently. When mannose-6 phosphorylated lysosomal enzymes were added to the culture medium of microglia, degradation of fAβ was increas...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2424018/ https://ncbi.nlm.nih.gov/pubmed/17222479 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2006.12.001 |
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