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Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome
Accumulation of β-amyloid (Aβ) and resultant inflammation are critical pathological features of Alzheimer disease (AD). Microglia, a primary immune cell in brain, ingests and degrades extracellular Aβ fibrils via the lysosomal system. Autophagy is a catabolic process that degrades native cellular co...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Landes Bioscience
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4198361/ https://ncbi.nlm.nih.gov/pubmed/25126727 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.29647 |
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