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Microglia do not take up soluble amyloid-beta peptides, but partially degrade them by secreting insulin-degrading enzyme
Microglia play important roles in the pathogenesis of Alzheimer’s disease (AD), in part, by affecting the clearance of amyloid-β (Aβ) peptides. Most studies, however, used synthetic soluble Aβ (sAβ) at higher concentrations. The exact mechanisms underlying microglia-mediated clearance of physiologic...
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| Publié dans: | Neuroscience |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7484427/ https://ncbi.nlm.nih.gov/pubmed/32697980 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2020.07.020 |
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