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What makes a kinase promiscuous for inhibitors?
ATP-competitive kinase inhibitors often bind several kinases due to the high conservation of the ATP binding pocket. Through clustering analysis of a large kinome profiling dataset we found a cluster of eight promiscuous kinases that on average bind more than five times more kinase inhibitors than t...
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| Publicado en: | Cell Chem Biol |
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| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6632086/ https://ncbi.nlm.nih.gov/pubmed/30612951 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2018.11.005 |
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