Unprecedently Large-Scale Kinase Inhibitor Set Enabling the Accurate Prediction of Compound–Kinase Activities: A Way toward Selective Promiscuity by Design?

[Image: see text] Drug discovery programs frequently target members of the human kinome and try to identify small molecule protein kinase inhibitors, primarily for cancer treatment, additional indications being increasingly investigated. One of the challenges is controlling the inhibitors degree of...

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Detalhes bibliográficos
Publicado no:J Chem Inf Model
Main Authors: Christmann-Franck, Serge, van Westen, Gerard J. P., Papadatos, George, Beltran Escudie, Fanny, Roberts, Alexander, Overington, John P., Domine, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5039764/
https://ncbi.nlm.nih.gov/pubmed/27482722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jcim.6b00122
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