Testing the Promiscuity of Commercial Kinase Inhibitors Against the AGC Kinase Group Using a Split-luciferase Screen

Using a newly developed competitive binding assay dependent upon the reassembly of a split reporter protein, we have tested the promiscuity of a panel of reported kinase inhibitors against the AGC group. Many non-AGC targeted kinase inhibitors target multiple members of the AGC group. In general, st...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Jester, Benjamin W., Gaj, Alicia, Shomin, Carolyn D., Cox, Kurt J., Ghosh, Indraneel
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2012
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328412/
https://ncbi.nlm.nih.gov/pubmed/22257127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201265f
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