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Selection of Cyclic-Peptide Inhibitors Targeting Aurora Kinase A: Problems and Solutions

The critical role of Aurora kinase in cell cycle progression and its deregulation in cancer has garnered significant interest. As such, numerous Aurora targeted inhibitors have been developed to date, almost all of which target the ATP cleft at the active site. These current inhibitors display polyp...

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Detalhes bibliográficos
Main Authors: Shomin, Carolyn D., Restituyo, Elizabeth, Cox, Kurt J., Ghosh, Indraneel
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3206593/
https://ncbi.nlm.nih.gov/pubmed/22004849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.09.049
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