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Selection of Cyclic-Peptide Inhibitors Targeting Aurora Kinase A: Problems and Solutions
The critical role of Aurora kinase in cell cycle progression and its deregulation in cancer has garnered significant interest. As such, numerous Aurora targeted inhibitors have been developed to date, almost all of which target the ATP cleft at the active site. These current inhibitors display polyp...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3206593/ https://ncbi.nlm.nih.gov/pubmed/22004849 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.09.049 |
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