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Staurosporine Tethered Peptide Ligands that Target cAMP-dependent Protein Kinase (PKA): Optimization and Selectivity Profiling
We have recently developed a fragment based selection strategy for targeting kinases, where a small molecule warhead can be non-covalently tethered to a phage-displayed library of peptides. This approach was applied to the conversion of the promiscuous kinase inhibitor, staurosporine, into a potent...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2749490/ https://ncbi.nlm.nih.gov/pubmed/19674907 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.07.056 |
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