Selective and competitive inhibition of kynurenine aminotransferase 2 by glycyrrhizic acid and its analogues

The enzyme kynurenine aminotransferase (KAT) catalyses the conversion of kynurenine (KYN) to kynurenic acid (KYNA). Although the isozymes KAT1–4 have been identified, KYNA is mainly produced by KAT2 in brain tissues. KNYA is an antagonist of N-methyl-D-aspartate and α-7-nicotinic acetylcholine recep...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Yoshida, Yukihiro, Fujigaki, Hidetsugu, Kato, Koichi, Yamazaki, Kyoka, Fujigaki, Suwako, Kunisawa, Kazuo, Yamamoto, Yasuko, Mouri, Akihiro, Oda, Akifumi, Nabeshima, Toshitaka, Saito, Kuniaki
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629613/
https://ncbi.nlm.nih.gov/pubmed/31308447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-46666-y
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