Selective and competitive inhibition of kynurenine aminotransferase 2 by glycyrrhizic acid and its analogues

The enzyme kynurenine aminotransferase (KAT) catalyses the conversion of kynurenine (KYN) to kynurenic acid (KYNA). Although the isozymes KAT1–4 have been identified, KYNA is mainly produced by KAT2 in brain tissues. KNYA is an antagonist of N-methyl-D-aspartate and α-7-nicotinic acetylcholine recep...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Yoshida, Yukihiro, Fujigaki, Hidetsugu, Kato, Koichi, Yamazaki, Kyoka, Fujigaki, Suwako, Kunisawa, Kazuo, Yamamoto, Yasuko, Mouri, Akihiro, Oda, Akifumi, Nabeshima, Toshitaka, Saito, Kuniaki
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629613/
https://ncbi.nlm.nih.gov/pubmed/31308447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-46666-y
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