Selective and competitive inhibition of kynurenine aminotransferase 2 by glycyrrhizic acid and its analogues

The enzyme kynurenine aminotransferase (KAT) catalyses the conversion of kynurenine (KYN) to kynurenic acid (KYNA). Although the isozymes KAT1–4 have been identified, KYNA is mainly produced by KAT2 in brain tissues. KNYA is an antagonist of N-methyl-D-aspartate and α-7-nicotinic acetylcholine recep...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Sci Rep
Hlavní autoři: Yoshida, Yukihiro, Fujigaki, Hidetsugu, Kato, Koichi, Yamazaki, Kyoka, Fujigaki, Suwako, Kunisawa, Kazuo, Yamamoto, Yasuko, Mouri, Akihiro, Oda, Akifumi, Nabeshima, Toshitaka, Saito, Kuniaki
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629613/
https://ncbi.nlm.nih.gov/pubmed/31308447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-46666-y
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky