Lipopolysaccharide shock reveals the immune function of indoleamine 2,3-dioxygenase 2 through the regulation of IL-6/stat3 signalling

Indoleamine 2,3-dioxygenase 2 (Ido2) is a recently identified catalytic enzyme in the tryptophan-kynurenine pathway that is expressed primarily in monocytes and dendritic cells. To elucidate the biological role of Ido2 in immune function, we introduced lipopolysaccharide (LPS) endotoxin shock to Ido...

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Udgivet i:Sci Rep
Main Authors: Yamamoto, Yasuko, Yamasuge, Wakana, Imai, Shinjiro, Kunisawa, Kazuo, Hoshi, Masato, Fujigaki, Hidetsugu, Mouri, Akihiro, Nabeshima, Toshitaka, Saito, Kuniaki
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6206095/
https://ncbi.nlm.nih.gov/pubmed/30374077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-34166-4
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