5′,8-Cyclopurine Lesions in DNA Damage: Chemical, Analytical, Biological, and Diagnostic Significance

Purine 5′,8-cyclo-2′-deoxynucleosides (cPu) are tandem-type lesions observed among the DNA purine modifications and identified in mammalian cellular DNA in vivo. These lesions can be present in two diasteroisomeric forms, 5′R and 5′S, for each 2′-deoxyadenosine and 2′-deoxyguanosine moiety. They are...

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Detalhes bibliográficos
Publicado no:Cells
Main Authors: Chatgilialoglu, Chryssostomos, Ferreri, Carla, Geacintov, Nicholas E., Krokidis, Marios G., Liu, Yuan, Masi, Annalisa, Shafirovich, Vladimir, Terzidis, Michael A., Tsegay, Pawlos S.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6628319/
https://ncbi.nlm.nih.gov/pubmed/31141888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8060513
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