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Nuclear Receptor 4A1 (NR4A1) Antagonists Induce ROS-dependent Inhibition of mTOR Signaling in Endometrial Cancer

OBJECTIVES: NR4A1 is overexpressed in many solid tumors, and the objectives of this study were to investigate the expression and functional role of this receptor in endometrial cancer cells and demonstrate that NR4A1 antagonist inhibit mTOR. METHODS: Ishikawa and Hec-1B endometrial cells were used a...

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Bibliographische Detailangaben
Veröffentlicht in:Gynecol Oncol
Hauptverfasser: Mohankumar, Kumaravel, Li, Xi, Sridharan, Subhashree, Karki, Keshav, Safe, Stephen
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6625344/
https://ncbi.nlm.nih.gov/pubmed/31053403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2019.04.678
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