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A Bis-Indole-Derived NR4A1 Antagonist Induces PD-L1 Degradation and Enhances Anti-Tumor Immunity

PD-L1 is expressed in tumor cells and its interaction with PD-1 plays an important role in evading immune surveillance; this can be overcome using PD-L1 or PD-1 immunotherapy antibodies. This study reports a novel approach for targeting PD-L1. In human breast cancer cell lines and 4T1 mouse mammary...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Karki, Keshav, Wright, Gus A., Mohankumar, Kumaravel, Jin, Un-Ho, Zhang, Xing-Han, Safe, Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7056589/
https://ncbi.nlm.nih.gov/pubmed/31911554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-2314
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