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Potent Inhibition of Breast Cancer by Bis-Indole-Derived Nuclear Receptor 4A1 (NR4A1) Antagonists

BACKGROUND: Nuclear receptor 4A1 (NR4A1) is overexpressed in mammary tumors, and the methylene-substituted bis-indole derivative 1,1-bis(3'-indolyl)-1-(p-hydroxyphenyl)methane (DIM-C-pPhOH) acts as an NR4A1 antagonist (inverse agonist) and inhibits NR4A1-regulated pro-oncogenic pathways/genes i...

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Detalhes bibliográficos
Publicado no:Breast Cancer Res Treat
Main Authors: Hedrick, Erik, Li, Xi, Cheng, Yating, Lacey, Alexandra, Mohankumar, Kumaravel, Zarei, Mahsa, Safe, Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6681651/
https://ncbi.nlm.nih.gov/pubmed/31119568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-019-05279-9
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