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Bis-indole derived nuclear receptor 4A1 (NR4A1) antagonists inhibit TGFβ-induced invasion of embryonal rhabdomyosarcoma cells

Transforming growth factor β (TGFβ) enhances invasion of breast and lung cancer cells through phosphorylation-dependent nuclear export of the nuclear receptor 4A1 (NR4A1, Nur77). This response is inhibited by the NR4A1 antagonist 1,1-bis(3’-indoly)-1-(p-hydroxyphenyl) methane (CDIM8) and we hypothes...

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Bibliografske podrobnosti
izdano v:Am J Cancer Res
Main Authors: Shrestha, Rupesh, Mohankumar, Kumaravel, Safe, Stephen
Format: Artigo
Jezik:Inglês
Izdano: e-Century Publishing Corporation 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7471359/
https://ncbi.nlm.nih.gov/pubmed/32905449
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