Bis-Indole–Derived NR4A1 Ligands and Metformin Exhibit NR4A1-Dependent Glucose Metabolism and Uptake in C2C12 Cells

Treatment of C2C12 muscle cells with metformin or the NR4A1 ligand 1,1-bis(3′-indolyl)-1-(p-hydroxyphenyl)methane (DIM-C-pPhOH) induced NR4A1 and Glut4 messenger RNA and protein expression. Similar results were observed with buttressed (3- or 3,5-substituted) analogs of DIM-C-pPhOH, including 1,1-bi...

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Detaylı Bibliyografya
Yayımlandı:Endocrinology
Asıl Yazarlar: Mohankumar, Kumaravel, Lee, Jehoon, Wu, Chia Shan, Sun, Yuxiang, Safe, Stephen
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Endocrine Society 2018
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5888234/
https://ncbi.nlm.nih.gov/pubmed/29635345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2017-03049
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