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INHIBITION OF NR4A1 PROMOTES ROS ACCUMULATION AND IL-24 – DEPENDENT GROWTH ARREST IN RHABDOMYOSARCOMA

Nuclear receptor 4A1 (NR4A1, Nur77) is overexpressed in Rhabdomyosarcoma (RMS), and inactivation of NR4A1 (siNR4A1) or treatment with the NR4A1 antagonist 1,1-bis(3’-indoly)-1-(p-hydroxy-phenyl)methane (DIM-C-pPhOH) has antiproliferative and pro-apoptotic effects on RMS cells. However, the mechanism...

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Publicat a:Mol Cancer Res
Autors principals: Hedrick, Erik, Mohankumar, Kumaravel, Lacey, Alexandra, Safe, Stephen
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6825581/
https://ncbi.nlm.nih.gov/pubmed/31462501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-19-0408
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