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NR4A1 Ligands as Potent Inhibitors of Breast Cancer Cell and Tumor Growth

SIMPLE SUMMARY: Bis-indole derived (CDIMs) bind the orphan nuclear receptor 4A1 (NR4A1) and inhibit NR4A1-regulated cancer cell and tumor growth. In this study a subset of 3,5-disubstituted phenyl CDIM compounds that bound NR4A1 were investigated in a breast cancer model. All of these analogs were p...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Cancers (Basel)
Päätekijät: Karki, Keshav, Mohankumar, Kumaravel, Schoeller, Abigail, Martin, Gregory, Shrestha, Rupesh, Safe, Stephen
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: MDPI 2021
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8198788/
https://ncbi.nlm.nih.gov/pubmed/34072371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13112682
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