The ESC: The Dangerous By-Product of V(D)J Recombination

V(D)J recombination generates antigen receptor diversity by mixing and matching individual variable (V), diversity (D), and joining (J) gene segments. An obligate by-product of many of these reactions is the excised signal circle (ESC), generated by excision of the DNA from between the gene segments...

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Udgivet i:Front Immunol
Main Authors: Smith, Alastair L., Scott, James N. F., Boyes, Joan
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6620893/
https://ncbi.nlm.nih.gov/pubmed/31333681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01572
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