Regulation of V(D)J recombination by nucleosome positioning at recombination signal sequences

A key component in the regulation of V(D)J recombination is control of the accessibility of RAG proteins to recombination signal sequences (RSS). Nucleosomes are known to inhibit this accessibility. We show here that the signal sequence itself represses accessibility by causing nucleosome positionin...

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Veröffentlicht in:	EMBO J
Hauptverfasser:	Baumann, Matthias, Mamais, Adamantios, McBlane, Fraser, Xiao, Hua, Boyes, Joan
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 2003
Schlagworte:	Articles
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC204470/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14517257/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg487
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