Vascular TSP1-CD47 signaling promotes sickle cell-associated arterial vasculopathy and pulmonary hypertension in mice

Pulmonary hypertension (PH) is a leading cause of death in sickle cell disease (SCD) patients. Hemolysis and oxidative stress contribute to SCD-associated PH. We have reported that the protein thrombospondin-1 (TSP1) is elevated in the plasma of patients with SCD and, by interacting with its recepto...

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Vydáno v:Am J Physiol Lung Cell Mol Physiol
Hlavní autoři: Novelli, Enrico M., Little-Ihrig, Lynda, Knupp, Heather E., Rogers, Natasha M., Yao, Mingyi, Baust, Jeffrey J., Meijles, Daniel, St. Croix, Claudette M., Ross, Mark A., Pagano, Patrick J., DeVallance, Evan R., Miles, George, Potoka, Karin P., Isenberg, Jeffrey S., Gladwin, Mark T.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2019
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6620668/
https://ncbi.nlm.nih.gov/pubmed/30892078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00302.2018
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