The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1

Senescent cells withdraw from the cell cycle and do not proliferate. The prevalence of senescent compared to normally functioning parenchymal cells increases with age, impairing tissue and organ homeostasis. A contentious principle governing this process has been the redox theory of aging. We linked...

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Dades bibliogràfiques
Publicat a:Sci Signal
Autors principals: Meijles, Daniel N., Sahoo, Sanghamitra, Al Ghouleh, Imad, Amaral, Jefferson H., Bienes-Martinez, Raquel, Knupp, Heather E., Attaran, Shireen, Sembrat, John C., Nouraie, Seyed M., Rojas, Mauricio M., Novelli, Enrico M., Gladwin, Mark T., Isenberg, Jeffrey S., Cifuentes-Pagano, Eugenia, Pagano, Patrick J.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679204/
https://ncbi.nlm.nih.gov/pubmed/29042481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaj1784
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