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The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1

Senescent cells withdraw from the cell cycle and do not proliferate. The prevalence of senescent compared to normally functioning parenchymal cells increases with age, impairing tissue and organ homeostasis. A contentious principle governing this process has been the redox theory of aging. We linked...

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Detalhes bibliográficos
Publicado no:Sci Signal
Main Authors: Meijles, Daniel N., Sahoo, Sanghamitra, Al Ghouleh, Imad, Amaral, Jefferson H., Bienes-Martinez, Raquel, Knupp, Heather E., Attaran, Shireen, Sembrat, John C., Nouraie, Seyed M., Rojas, Mauricio M., Novelli, Enrico M., Gladwin, Mark T., Isenberg, Jeffrey S., Cifuentes-Pagano, Eugenia, Pagano, Patrick J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679204/
https://ncbi.nlm.nih.gov/pubmed/29042481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaj1784
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