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Bridged tetrahydroisoquinolines as selective NADPH oxidase 2 (Nox2) inhibitors
(1SR,4RS)-3,3-Dimethyl-1,2,3,4-tetrahydro-1,4-(epiminomethano)naphthalenes were synthesized in 2-3 steps from commercially available materials and assessed for specificity and effectiveness across a range of Nox isoforms. The N-pentyl and N-methylenethiophene substituted analogs 11g and 11h emerged...
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| Glavni autori: | , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2013
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3897123/ https://ncbi.nlm.nih.gov/pubmed/24466406 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C3MD00061C |
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