Bridged tetrahydroisoquinolines as selective NADPH oxidase 2 (Nox2) inhibitors

(1SR,4RS)-3,3-Dimethyl-1,2,3,4-tetrahydro-1,4-(epiminomethano)naphthalenes were synthesized in 2-3 steps from commercially available materials and assessed for specificity and effectiveness across a range of Nox isoforms. The N-pentyl and N-methylenethiophene substituted analogs 11g and 11h emerged...

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Bibliografiske detaljer
Main Authors: Cifuentes-Pagano, Eugenia, Saha, Jaideep, Csányi, Gábor, Ghouleh, Imad Al, Sahoo, Sanghamitra, Rodríguez, Andrés, Wipf, Peter, Pagano, Patrick J., Skoda, Erin M.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3897123/
https://ncbi.nlm.nih.gov/pubmed/24466406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C3MD00061C
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